According to a new study, we have not even begun to see the true impact of glyphosate.

This new study by Kubsad et al, published in Scientific Reports shows that glyphosate alone, not the surfactants, impacts the germline of the fetus in female rats. The germline means the sperm and eggs inside the fetus, which will ultimately become the fetuses’ offspring. The sperm and eggs are harmed by glyphosate, affecting the health and viability of future generations.

There has been considerable controversy about whether or not it is glyphosate alone or the surfactants, also known as co-formulants, in glyphosate herbicides that cause harm. This point is legally significant. The EPA only requires safety studies on the one declared “active” chemical ingredient in glyphosate herbicides or any pesticide for that matter, not the full formulation which, includes the co-formulants. Lawsuits worth billions of dollars are being contested based on the industry science and EPA policies. Scientists who asserted that only the co-formulants caused harm and not glyphosate alone were inadvertently supporting Monsanto’s assertion that glyphosate (alone) does not cause harmful effects. That assessment could lead to another 15-year approval from the EPA.

一方、共製剤が害を及ぼす（そして非活性ではない）ことを示す実質的な証拠は、完全な製剤に基づいて安全性研究を提出することを製造業者に要求する方針変更につながる可能性があります。完全な製剤規制は、待望の政策転換であり、安全性を正確に規制する唯一の方法です。

目前の問題は、グリホサートの現在のレビューと、EPAが使用ライセンスを取り消すか、さらに15、10、または5年間再承認するかどうかです。グリホサートの研究のみをレビューした場合、すぐに急性毒性がないため（96時間以内に50％以上の動物を殺す）、再承認する可能性があります。による セラリーニらの研究、界面活性剤は1000倍毒性があります。それでも、完全な定式化は規制に含まれていないため、EPAはこれらの影響を無視する可能性があります。したがって、グリホサート単独の長期的なエピジェネティックな影響を示すこの研究は重要であり、EPAがそれを考慮した場合、グリホサートの禁止つながる可能性があります。

Recently, the EPA has determined that glyphosate herbicides do harm 93% of endangered species and 97% of their critical habitats. No doubt, one of the ways the species are harmed is the manner in which this new study describes, epigenetically. When a species cannot reproduce, the species dies off.

新しい研究の次の評価は、グリホサートの専門家でありMITの科学者であるステファニーセネフ博士によって提供されました。

This is a follow-on paper from earlier work the same authors have done where they've shown that low dose glyphosate exposure to pregnant rats results in serious damage to their grandpups and their great grandpups.  It's an extraordinary finding, but it is characteristic of toxic chemicals that are endocrine disruptors.

It's the germline in the fetus that is being directly affected.  Those are the cells that will eventually become eggs and sperm for the next generation.  They get exposed directly to glyphosate and they respond through epigenetic modifications to the DNA.  This is not a DNA mutation, but rather a chemical modification of the DNA such as methylation of certain nucleotides in the DNA, that alter the expression of the genes and therefore the metabolic policy of the progeny that are descended from the exposed fetus.

This is a new angle to the research where they characterized differential DNA methylation regions (DMRs) in sperm taken from the sequence of generations. The attached figure is quite striking because you can see that the top items in the list have larger responses in later generations.  They also linked the patterns seen to various known diseases.

"Epigenetic analysis of the F1, F2, and F3 generation sperm identified differential DNA methylation regions (DMRs). A number of DMR associated genes were identified and previously shown to be involved in pathologies."

Numerous animal studies have shown that glyphosate-based herbicides, full formulation, contribute to cancer, autism, thyroid disease, neurotoxicity, birth defects, diminished gut bacteria, and therefore weakened immune systems, and can cause fatty liver disease. Clearly, glyphosate and glyphosate herbicides’ full formulations are harmful, not only to current generations but to future generations as well.

EPAによると、米国では年間3億ポンドのグリホサートが農業と造園に使用されています。除草剤は20年間土壌に残ると報告されています。グリホサートの広範な使用、寿命、および生殖器への影響を考慮すると、人類と地球上の生命の将来は、それを禁止するかどうかのいくつかの政策決定者の決定に依存する可能性があります。

The EPA is accepting comments until 3月 12 about the impact of glyphosate herbicides on endangered species. We urge our readers to take action and tell the EPA to ban all glyphosate use immediately.COMMENT BY 3月 12, 2021. Commenters are instructed to post comments to the BE docket. Click on www.regulations.gov.  Copy and paste EPA-HQ-OPP-2020-0585 in the search bar. Comment and attach studies from www.momsacrossamerica.org/data 

View the prepublication notice of the biological evaluation for glyphosate.