A comprehensive carcinogenicity study on glyphosate, the world's most used herbicide, involving scientists from Europe and the U.S., has found that low doses of the controversial weed killer cause multiple types of cancer in rats at levels of exposure lower than previously deemed safe.

Sustainable Pulse released the groundbreaking news of the long-awaited global study on glyphosate in the article: "International Study Reveals Glyphosate Weed Killers Cause," stating:

“We observed early onset and early mortality for a number of rare malignant cancers, including leukemia, liver, ovary, and nervous system tumors. Notably, approximately half of the deaths from leukemia seen in the glyphosate and GBHs treatment groups occurred at less than one year of age, comparable to less than 35-40 years of age in humans. By contrast, no case of leukemia was observed in the first year of age in more than 1600 Sprague Dawley historical controls in carcinogenicity studies conducted by the Ramazzini Institute and the National Toxicology Program (NTP),” stated Dr. Daniele Mandrioli, Director of the Cesare Maltoni Cancer Research Center of the Ramazzini Institute and Principal Investigator of the study.

“Our findings reinforce IARC’s classification of glyphosate as a probable human carcinogen and are consistent with experimental animal studies as well as human correlational and weight-of-evidence evaluations that have reported associations between glyphosate exposure and certain cancers, particularly hematological malignancies,” said Dr. Melissa Perry, study co-author and Environmental Epidemiologist at George Mason University College of Public Health.

Moms Across America urges an immediate international ban of glyphosate herbicides to support consistently safe trade products and the health of international communities.

“We Americans have a physical, mental, and reproductive health crisis, and independent science shows that glyphosate is a major contributing factor to all of these issues. Export partners such as the people of Japan report skyrocketing infertility, depression, suicide, autism, and cancer rates, all connected to glyphosate use. It is time for our trade agreements to include an international ban on glyphosate use to ensure the safety of our trade partners' health and the quality of crop exports,” stated Zen Honeycutt of Moms Across America.

Glyphosate is the most widely used herbicide in the world, and pushback against a ban or restrictions will be and has been enormous. Bayer/Monsanto and Syngenta/ChemChina have spent tens of millions lobbying our elected state officials to pass laws to protect them and the makers of 15,000 chemicals from lawsuits and accountability for safety. Bills in seven states have been defeated; two states passed one, and North Carolina's is pending.

The manipulation of our government to protect companies that make chemicals clearly contributing to our national health crisis is a deliberate destruction of democracy.

This news comes at a time when Congress is looking to pass an additional $30 billion subsidy for commodity crops such as GMO corn and soy, bringing the total to $75 billion or $7.5 billion a year. This means our Congress will be awarding Big Ag (as the farmers spend that subsidy money on GMO seeds, glyphosate, and toxic agrochemicals) more money than the total budget of the FDA, which is $7.2 billion a year. This misallocation of funds is outrageous.

What if we, as a nation, did what the Mayor of Barjac did—which was to create a market for organic food by diverting funds from chemical farmers to the schools for organic food, compelling the farmers to go organic and ensuring their security? Dividing $30 billion among 30 million school meals served daily over a typical 180-day school year yields approximately $5.56 per meal.

In fiscal year 2023, the National School Lunch Program (NSLP) served over 4.6 billion lunches at a total cost of $17.2 billion, averaging about $3.74 per meal ($2.00 for food and $1.74 for labor). Therefore, a $30 billion investment could significantly enhance the quality and sustainability of school meal programs, potentially allowing for improvements in nutritional standards, meal variety, and support for local food systems.

More about the study:

In this long-term study, published on Tuesday, glyphosate alone and two commercial glyphosate-based formulations, Roundup BioFlow (MON 52276) used in the EU and Ranger Pro (EPA 524-517) used in the U.S., were administered to rats via drinking water beginning in prenatal life, at doses of 0.5, 5, and 50 mg/kg body weight/day for 2 years. These doses are currently considered safe by regulatory agencies and correspond to the EU Acceptable Daily Intake (ADI) and the EU’s No Observed Adverse Effect Level (NOAEL) for glyphosate. The EU levels are considerably lower than what the USA allows on crops.

In all 3 treatment groups, increased incidences of benign and malignant tumors at multiple anatomic sites were observed compared to controls. These tumors arose in haemolymph reticular tissues (leukemia), skin, liver, thyroid, nervous system, ovary, mammary gland, adrenal glands, kidney, urinary bladder, bone, endocrine pancreas, uterus, and spleen (hemangiosarcoma). Increased incidences occurred in both sexes. Most of these involved tumors that are rare in Sprague Dawley rats (background incidence < 1%) with 40% of leukemia deaths in the treated groups occurring in early life, and increased early deaths were also observed for other solid tumors.

The multi-institutional Global Glyphosate Study is being led by the Cesare Maltoni Cancer Research Center of the Ramazzini Institute in Italy and involves scientists from Boston College, George Mason University, King’s College London, Icahn School of Medicine at Mount Sinai, Scientific Centre of Monaco, University of Bologna, the Institute of Agricultural Biology and Biotechnology of the Italian National Research Council, the Italian National Institute of Health, and the National Food Safety Committee of the Italian Ministry of Health. The Cesare Maltoni Cancer Research Center of the Ramazzini Institute, with over 200 compounds studied in over 50 years, is the largest bioassay program in the EU; vinyl chloride, asbestos, benzene, and radio frequencies are among the carcinogenic agents that have been investigated in its laboratory. Most recently, the Cesare Maltoni Cancer Research Center of the Ramazzini Institute also published a peer-reviewed report in collaboration with the U.S. National Institute of Environmental Health Sciences (NIEHS) on the toxicological effects of nicotine. These new results provide robust evidence supporting the International Agency for Research on Cancer’s (IARC) conclusion in 2015 that there is “sufficient evidence of carcinogenicity of glyphosate in experimental animals.” Furthermore, the study’s data are consistent with epidemiological evidence on the carcinogenicity of glyphosate and glyphosate-based herbicides.
The Global Glyphosate Study is the most comprehensive toxicological study ever conducted on glyphosate and glyphosate-based herbicides. It aims to provide vital data for government regulators, policymakers, and the general public. The study is examining the impacts of glyphosate and glyphosate-based herbicides on carcinogenicity, neuro-developmental toxicity, multi-generational effects, organ toxicity, endocrine disruption, and prenatal developmental toxicity.

"This robust study, based on a protocol encompassing pre- and post-natal development, fulfills the need for sound scientific evidence on the toxicology of glyphosate. The results highlight the tumorigenic potential of glyphosate and glyphosate-based products at dose levels considered as “safe.” This new evidence has to be carefully considered by the regulatory authorities globally," added Dr. Alberto Mantovani, study co-author and member of the Italian National Food Safety Committee (CNSA).

The GGS’s findings on glyphosate’s toxicity to the microbiome, which were peer-reviewed and published in late 2022 and presented at the EU Parliament in 2023, also showed adverse effects at doses that are currently considered safe in the EU (0.5 mg/kg bw/day, equivalent to the EU Acceptable Daily Intake).

The GGS also previously published a pilot study, which showed endocrine and reproductive toxicity in rats at glyphosate doses currently considered safe by regulatory agencies in the U.S. (1.75 mg/kg bw/day). These findings were later confirmed in a human population of mothers and newborns exposed to glyphosate during pregnancy.

The next step in the GGS will be the neurotoxicity arm, which is vital for understanding any role glyphosate and glyphosate-based herbicides may be playing in the rise of neurological-related diseases and disorders.

"The findings from this carefully conducted study, and especially the observation that prenatal exposures of infant rats to glyphosate during pregnancy increase incidence and mortality from early-life leukemia, is a powerful reminder of human infants' great vulnerability to toxic chemicals and a strong reason to eliminate glyphosate from the production of foods consumed by pregnant women and their children," concluded Dr. Philip Landrigan, study co-author and Director of the Program for Global Public Health and the Common Good at Boston College.

Media Contact:
Dr. Daniele Mandrioli
Director, Cesare Maltoni Cancer Research Center
Ramazzini Institute
[email protected]
www.glyphosatestudy.org